Science | Nature | Cell | View More
Natural Products
Wallichinine
Wallichinine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Wallichinine
Price:
CAS No.: 125292-97-9
Catalog No.: CFN96307
Molecular Formula: C22H26O5
Molecular Weight: 370.5 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Oil
Source: The stems of Piper wightii.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Vin?a Institute of Nuclear Scie... (Serbia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Maryland School o... (USA)
  • University of Ioannina (Greece)
  • Monash University Malaysia (Malaysia)
  • University of Wisconsin-Madison (USA)
  • Almansora University (Egypt)
  • Chiang Mai University (Thailand)
  • University of British Columbia (Canada)
  • Uniwersytet JagielloĊ„ski w Kra... (Poland)
  • University of Brasilia (Brazil)
  • More...
Package
Featured Products
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Falcarindiol

Catalog No: CFN98220
CAS No: 225110-25-8
Price: $118/20mg
Nodakenetin

Catalog No: CFN98788
CAS No: 495-32-9
Price: $188/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Campesterol

Catalog No: CFN92204
CAS No: 474-62-4
Price: $188/10mg
Reynosin

Catalog No: CFN98344
CAS No: 28254-53-7
Price: $ /
Pseudoprotodioscin

Catalog No: CFN90694
CAS No: 102115-79-7
Price: $138/20mg
Crategolic acid

Catalog No: CFN98669
CAS No: 4373-41-5
Price: $80/20mg
Nothofagin

Catalog No: CFN92888
CAS No: 11023-94-2
Price: $ / mg
Erigoster B

Catalog No: CFN93294
CAS No: 849777-61-3
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR).
Targets: PAFR | ABCB1 | ATPase
In vitro:
Yao Xue Xue Bao. 1989;24(6):438-43.
The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim[Pubmed: 2609983]
Platelet activating factor (PAF) is a highly potent endogenous phospholipid mediator, involved in various inflammatory and cardiovascular disorders.
METHODS AND RESULTS:
As part of a research program dealing with PAF inhibitors isolated from Piper plant species, we have isolated kadsurenone (I), denudatin B (II), and N-isobutyl-deca-trans-2-trans-4-dienamide (III) from Piped wallichii (Miq.) Hand-Mazz. and P. hancei Maxim. In a continuing search for potential PAF inhibitor from plants, using PAF induced platelet aggregation as a guide, a new neolignan named hancinone D (IV) was isolated from P. hancei maxim. By X-ray analysis it was identified as a racemate. The X-ray analysis led to a revision of the previously made structure assignment of hancinone C. Another new neolignan named Wallichinine (V), which was identified as an analogue of (IV), along with the known compounds hancinone C (VI), galgravin (VII), dihydropiperlonguminine (VIII) and crotepoxide (IX) were isolated from P. wallichii (Miq.) Hand-Mazz. The structure determination was based upon spectroscopic analysis.
CONCLUSIONS:
All of the compounds were for the first time obtained from both plants. In the test of platelet aggregation caused by PAF, I, II, V, VI, VII showed inhibitory activity, whereas III, IV, VII, IX showed no activity.
Wallichinine Description
Source: The stems of Piper wightii.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
N-trans-caffeoyloctopamine

Catalog No: CFN95264
CAS No: 1378868-10-0
Price: $413/5mg
Isospinosin

Catalog No: CFN95350
CAS No: 89701-83-7
Price: $318/5mg
9-Hydroxy-O-senecioyl-8,9-dihydroo...

Catalog No: CFN95274
CAS No: 31456-63-0
Price: $318/5mg
Arjunglucoside I

Catalog No: CFN95049
CAS No: 62319-70-4
Price: $268/10mg
Epigambogellic acid

Catalog No: CFN95438
CAS No: 1352191-85-5
Price: $318/5mg
Citrusin B

Catalog No: CFN95178
CAS No: 105279-10-5
Price: $388/5mg
Naringin 6''-acetate

Catalog No: CFN95418
CAS No: 139934-60-4
Price: $318/5mg
5-O-Coumaroylquinic acid

Catalog No: CFN95507
CAS No: 32451-86-8
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6991 mL 13.4953 mL 26.9906 mL 53.9811 mL 67.4764 mL
5 mM 0.5398 mL 2.6991 mL 5.3981 mL 10.7962 mL 13.4953 mL
10 mM 0.2699 mL 1.3495 mL 2.6991 mL 5.3981 mL 6.7476 mL
50 mM 0.054 mL 0.2699 mL 0.5398 mL 1.0796 mL 1.3495 mL
100 mM 0.027 mL 0.135 mL 0.2699 mL 0.5398 mL 0.6748 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Am J Transl Res. 2016 Jul 15;8(7):2969-80.
Wallichinine reverses ABCB1-mediated cancer multidrug resistance.[Pubmed: 27508017]
Overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR). Wallichinine is a compound isolated from piper wallichii and works as an antagonist of platelet activiating factor receptor to inhibit the gathering of blood platelet.
METHODS AND RESULTS:
In this study, we investigate the effect of Wallichinine on cancer MDR mediated by ABCB1 transporter. Wallichinine significantly potentiates the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells. Furthermore, Wallichinine do not alter the sensitivity of non-ABCB1 substrate cisplatin. Mechanistically, Wallichinine blocks the drug-efflux activity of ABCB1 to increase the intracellular accumulation of rhodamine 123 and doxorubicin and stimulates the ATPase of ABCB1 without alteration of the expression of ABCB1. The predicted binding mode shows the hydrophobic interactions of Wallichinine within the large drug binding cavity of ABCB1.
CONCLUSIONS:
At all, our study of the interaction of Wallichinine with ABCB1 presented herein provides valuable clues for the development of novel MDR reversal reagents from natural products.
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Falcarindiol

Catalog No: CFN98220
CAS No: 225110-25-8
Price: $118/20mg
Nodakenetin

Catalog No: CFN98788
CAS No: 495-32-9
Price: $188/20mg
Polyphyllin D

Catalog No: CFN90255
CAS No: 50773-41-6
Price: $118/20mg
Campesterol

Catalog No: CFN92204
CAS No: 474-62-4
Price: $188/10mg
Reynosin

Catalog No: CFN98344
CAS No: 28254-53-7
Price: $ /
Pseudoprotodioscin

Catalog No: CFN90694
CAS No: 102115-79-7
Price: $138/20mg
Crategolic acid

Catalog No: CFN98669
CAS No: 4373-41-5
Price: $80/20mg
Nothofagin

Catalog No: CFN92888
CAS No: 11023-94-2
Price: $ / mg
Erigoster B

Catalog No: CFN93294
CAS No: 849777-61-3
Price: $ / mg
Tags: buy Wallichinine | Wallichinine supplier | purchase Wallichinine | Wallichinine cost | Wallichinine manufacturer | order Wallichinine | Wallichinine distributor