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    Isomucronulatol
    Information
    CAS No. 52250-35-8 Price $218 / 10mg
    Catalog No.CFN90839Purity>=98%
    Molecular Weight302.3Type of CompoundPhenols
    FormulaC17H18O5Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Isomucronulatol Description
    Source: The roots of Astragalus membranaceus
    Biological Activity or Inhibitors: 1. Isoliquiritigenin and liquiritigenin exhibit significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC 50 values ranging from 2.7 to 6.102uM, isoliquiritigenin also shows a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC 50 value of 20.102 uM, they have potential anti-inflammatory effects.
    2. Isomucronulatol exhibits noticeable ABTS+ scavenging activity, it exhibits moderate inhibition against butyrylcholinesterase.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
    5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
    10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
    50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
    100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isomucronulatol References Information
    Citation [1]

    Arch. Pharm. Res. 2014, 37(2):186-92.

    Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed: 23771500 ]
    Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5), formononetin 7-O-β-D-glucoside (6), daidzein (7), daidzein 7-O-β-D-glucoside (8), methylnissolin (9), methylnissolin 3-O-β-D-glucoside (10), Isomucronulatol (11), and Isomucronulatol 7-O-β-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.
    Citation [2]

    Food Chem. 2011, 126(1):31-8.

    Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical-scavenging activity-guided fractionation[Reference: WebLink]
    From the acetone extract of Micromeria cilicica, two new (1 and 2) and five known (3-7) compounds were obtained through radical-scavenging activity guided isolation. Structures of the compounds were identified as piperitone 7-O-β-d-glucoside (1), isothymonin 4′-methyl ether (2), sudachitin (3), Isomucronulatol (4), rutin (5), ursolic acid (6) and saccharose (7), based on UV, 1D-and 2D-NMR and mass spectroscopic techniques. Among the pure compounds, rutin (5) showed the strongest lipid peroxidation inhibition and antiradical activity while both sudachitin (3) and Isomucronulatol (4) exhibited noticeable ABTS ⁺ scavenging activity. The anticholinesterase activity of the compounds (1-7) was also determined. Against acetylcholinesterase, they exhibited weak inhibition while compounds 3, 4 and 6 exhibited moderate inhibition against butyrylcholinesterase.