4'-Demethylpodophyllotoxin | CAS:40505-27-9

4'-Demethylpodophyllotoxin

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	4'-Demethylpodophyllotoxin
Price:	$40 / 20mg
CAS No.:	40505-27-9
Catalog No.:	CFN90483
Molecular Formula:	C₂₁H₂₀O₈
Molecular Weight:	400.37 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The herbs of Dysosma pleiantha (Hance) Woodson.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $16.9 / In-stock
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Description:

4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines.

In vitro:

Chem Biol Interact. 2014 Oct 18;224C:100-107.

4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed: 25446499]

We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity.
METHODS AND RESULTS:
The present study led to the isolation of six known aryltetralin-type lignans designated as 4'-demethyl-deoxypodophyllotoxin (1), podophyllotoxin (2), 4'-Demethylpodophyllotoxin (3), podophyllotoxin-4-O-β-d-glucopyranoside (4), 4'-demethyl-deoxypodophyllotoxin-4-O-β-d-glucopyranoside (5), 4'-demethyl-podophyllotoxin-4-O-β-d-glucopyranoside (6), along with three known flavones Kaempferol (7), Quercetin (8), Astragalin (9) from the root of P. hexandrum. Compounds (1-9) exhibited the remarkable cytotoxic potential in diverse cancer cell lines.

4'-Demethylpodophyllotoxin Description

Source:	The herbs of Dysosma pleiantha (Hance) Woodson.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4977 mL	12.4884 mL	24.9769 mL	49.9538 mL	62.4422 mL
5 mM	0.4995 mL	2.4977 mL	4.9954 mL	9.9908 mL	12.4884 mL
10 mM	0.2498 mL	1.2488 mL	2.4977 mL	4.9954 mL	6.2442 mL
50 mM	0.05 mL	0.2498 mL	0.4995 mL	0.9991 mL	1.2488 mL
100 mM	0.025 mL	0.1249 mL	0.2498 mL	0.4995 mL	0.6244 mL

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