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4'-Demethylpodophyllotoxin
4'-Demethylpodophyllotoxin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 4'-Demethylpodophyllotoxin
Price: $40 / 20mg
CAS No.: 40505-27-9
Catalog No.: CFN90483
Molecular Formula: C21H20O8
Molecular Weight: 400.37 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Dysosma pleiantha (Hance) Woodson.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $16.9 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 4'-Demethylpodophyllotoxin exhibits the remarkable cytotoxic potential in diverse cancer cell lines.
In vitro:
Chem Biol Interact. 2014 Oct 18;224C:100-107.
4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells.[Pubmed: 25446499]
We investigated the root of Podophyllum hexandrum as a potential source of lead bioactive metabolites with anticancer activity.
METHODS AND RESULTS:
The present study led to the isolation of six known aryltetralin-type lignans designated as 4'-demethyl-deoxypodophyllotoxin (1), podophyllotoxin (2), 4'-Demethylpodophyllotoxin (3), podophyllotoxin-4-O-β-d-glucopyranoside (4), 4'-demethyl-deoxypodophyllotoxin-4-O-β-d-glucopyranoside (5), 4'-demethyl-podophyllotoxin-4-O-β-d-glucopyranoside (6), along with three known flavones Kaempferol (7), Quercetin (8), Astragalin (9) from the root of P. hexandrum. Compounds (1-9) exhibited the remarkable cytotoxic potential in diverse cancer cell lines.
4'-Demethylpodophyllotoxin Description
Source: The herbs of Dysosma pleiantha (Hance) Woodson.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

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Sci Adv. 2018 Oct 24;4(10): eaat6994.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4977 mL 12.4884 mL 24.9769 mL 49.9538 mL 62.4422 mL
5 mM 0.4995 mL 2.4977 mL 4.9954 mL 9.9908 mL 12.4884 mL
10 mM 0.2498 mL 1.2488 mL 2.4977 mL 4.9954 mL 6.2442 mL
50 mM 0.05 mL 0.2498 mL 0.4995 mL 0.9991 mL 1.2488 mL
100 mM 0.025 mL 0.1249 mL 0.2498 mL 0.4995 mL 0.6244 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Acacetin

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CAS No: 480-44-4
Price: $30/20mg
Polygalacin D

Catalog No: CFN93351
CAS No: 66663-91-0
Price: $/mg
Pinoresinol diglucoside

Catalog No: CFN99994
CAS No: 63902-38-5
Price: $100/20mg
Isoferulic acid

Catalog No: CFN98282
CAS No: 25522-33-2
Price: $50/20mg
Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg
Glycitein

Catalog No: CFN99106
CAS No: 40957-83-3
Price: $70/20mg
1-Dehydro-10-gingerdione

Catalog No: CFN92374
CAS No: 136826-50-1
Price: $ / mg
Nerolidol

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Price: $30/20mg
(+)-Taxifolin

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Dantron

Catalog No: CFN99271
CAS No: 117-10-2
Price: $30/20mg
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