| Structure Identification: |
| Chinese Journal of Natural Medicines,2008,6(3):201-4. | | Homoisoflavonoids from Ophiopogon japonicus and Its Oxygen Free Radicals(OFRs) Scavenging Effects[Pubmed: 12444717] | To investigate the OFRs scavenging activities of homoisoflavonoids from the fibrous root of Ophiopogon japonicus.
METHODS AND RESULTS:
The scavenging effect of homoisoflavonoids isolated from O.japonicus extracts was examined on superoxide anion(O2·-),hydroxyl radical(·OH),and hydrogen peroxide(H2O2) by chemiluminescence.Ten homoisoflavonoids were obtained from O.japonicus extracts.They were identified as methylophiopogonanone A(1),methylophiopogonanone B(2),ophiopogonanone A(3),ophiopogonanone E(4),5,7-dihydroxy-6,8-dimethyl-3-(4'-hydroxy-3',5'-methoxybenzyl) chroman-4-one(5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one,5),methylophiopogonone A(6),methylophiopogonone B(7),desmethylisoophiopogonone B(8),5,7,2'-trihydroxy-8-methyl-3-(3',4'-methylenedioxybenzyl) chromone(9) and 5,7,2'-trihydroxy-6,8-dimethyl-3-(3',4'-methylenedioxybenzyl) chromone(10).
CONCLUSIONS:
Compounds 8 and 9 were firstly isolated from O.japonicus.The majority of homoisoflavonoids could scavenge ·OH and H2O2 in vitro to a certain extent,and their bioactivities should be related with the respective structures. | | Natural Medicines,1998,52:145-50. | | Cytotoxic Components of Ophiopogonis Tuber.[Reference: WebLink] |
METHODS AND RESULTS:
Nine compounds were isolated from an AcOEt extract of Ophiopogonis Tuber and showed a strong cytotoxic activity on HeLa-S_3 cell. Two of them were new compounds and their structures were established as 7, 8-dihydroxy-6-methyl-3-(2, 4-dimethoxy-benzyl) chroman-4-one and 5, 7-dihydroxy-6, 8-dimethyl-3-(4-hydroxy-3, 5-dimethoxy-benzyl) chroman-4-one(5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one) by their ^1H-NMR, ^<13>C-NMR and HR-MS spectra.
CONCLUSIONS:
The original plant of the crude drug used in this experiment was identified as Ophiopogon chekiangensis by microscopic examination. |
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