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    Natural Products
    7alpha,15-Dihydroxydehydroabietic acid
    7alpha,15-Dihydroxydehydroabietic acid
    Information
    CAS No. 155205-64-4 Price
    Catalog No.CFN89394Purity>=98%
    Molecular Weight332.43Type of CompoundDiterpenoids
    FormulaC20H28O4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    7alpha,15-Dihydroxydehydroabietic acid

    7alpha,15-Dihydroxydehydroabietic acid
    Product Name 7alpha,15-Dihydroxydehydroabietic acid
    CAS No.: 155205-64-4
    Catalog No.: CFN89394
    Molecular Formula: C20H28O4
    Molecular Weight: 332.43 g/mol
    Purity: >=98%
    Type of Compound: Diterpenoids
    Physical Desc.: Powder
    Targets: p53
    Source: The caulis and leaves of Callicarpa kochiana.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Nutrients.2020, 12(5):1242.
  • Front Immunol. 2020, 11:62.
  • Analytical Methods2018, 10(27)
  • HortTechnology2016, 26(6):816-819
  • Food Chem.2019, 278:683-691
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • J Biochem Mol Toxicol.2017, 31(9)
  • Processes2020, 8(12),1540.
  • Academic J of Second Military Medical University2019, 40(1)
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cytotoxic Compound Library
  • Diterpenoids Compound Library
  • p53 Inhibitor Library
  • Biological Activity
    Description: 7alpha,15-Dihydroxydehydroabietic acid may exhibit significant cytotoxic activity.
    Targets: p53
    In vitro:
    Chem Biodivers. 2017 Apr;14(4).
    Pinecone of Pinus koraiensis Inducing Apoptosis in Human Lung Cancer Cells by Activating Caspase-3 and its Chemical Constituents.[Pubmed: 28027428]
    Pinecones from Pinus koraiensisSiebold & Zucc. (Pinaceae), which have historically been treated as an undesired waste by-product in the processing of seeds, have recently been shown to contain ingredients with potent biological activities, such as polyphenols exhibiting antitumor activity.
    METHODS AND RESULTS:
    With this study, we seek to broaden our understanding of antitumor compounds contained in these pinecones beyond just polyphenols. We found that the water extract of P. koraiensis pinecones exhibits significant cytotoxic activity, with IC50 values ranging from 0.62 to 1.73 mg/ml in four human lung cancer cell lines, A549, H1264, H1299, and Calu-6, irrespective of their p53 status. We also demonstrate that pinecone water extract induces apoptosis associated with caspase-3 activation in the same cancer cell lines. Chemical investigation of the pinecone water extract revealed eight main components (1 - 8), and their structures were identified as dehydroabietic acid (1), 15-hydroxy-7-oxodehydroabietic acid (2), 7β,15-dihydroxydehydroabietic acid (3), β-d-glucopyranosyl labda-8(17,13)-diene-(15,16)-lactone-19-oate (4), 7alpha,15-Dihydroxydehydroabietic acid(5), (+)-(1S,2S,4R)-limonene-1,2-diol (6), sobrerol (7), and 4-hydroxybenzoic acid (8).
    CONCLUSIONS:
    These findings suggest a novel biological application of P. koraiensis pinecones in combatting human lung cancer, and further identify the major compounds that could contribute to this anticancer activity.
    7alpha,15-Dihydroxydehydroabietic acid Description
    Source: The caulis and leaves of Callicarpa kochiana.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0082 mL 15.0408 mL 30.0815 mL 60.163 mL 75.2038 mL
    5 mM 0.6016 mL 3.0082 mL 6.0163 mL 12.0326 mL 15.0408 mL
    10 mM 0.3008 mL 1.5041 mL 3.0082 mL 6.0163 mL 7.5204 mL
    50 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.2033 mL 1.5041 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Fitoterapia. 2012 Jan;83(1):1-5.
    Two new abietane diterpenoids from the caulis and leaves of Callicarpa kochiana.[Pubmed: 21983345]
    Previous studies revealed that diterpenoids from Callicarpa genus were mainly of clerodane-type and phyllocladane-type, and abietane-type diterpenoids were seldom reported.
    METHODS AND RESULTS:
    In this paper, we reported two new abietane diterpenoids, kochianic acid A (1) and kochianic acid B (2), together with two known abietane-type diterpenoids, pedunculatic acid B (3) and 7alpha,15-Dihydroxydehydroabietic acid(4), which were all isolated from Callicarpa kochiana.
    CONCLUSIONS:
    The structures of the new compounds 1 and 2 were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, ROESY and finally confirmed by single-crystal X-ray diffraction.
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