Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Apigenin 7-O-methylglucuronide
    Information
    CAS No. 53538-13-9 Price
    Catalog No.CFN98894Purity>=98%
    Molecular Weight460.4 Type of CompoundFlavonoids
    FormulaC22H20O11Physical DescriptionYellow powder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Queensland (Australia)
  • University of Mysore (India)
  • University of Otago (New Zealand)
  • Universidad Miguel Hern├índez (Spain)
  • University of Illinois (USA)
  • National Cancer Center Research... (Japan)
  • VIB Department of Plant Systems... (Belgium)
  • Universidade da Beira Interior (Germany)
  • Mahatma Gandhi University (India)
  • University Medical Center Mainz (Germany)
  • University of Toronto (Canada)
  • More...
  • Package
    Featured Products
    Germacrone

    Catalog No: CFN98133
    CAS No: 6902-91-6
    Price: $40/20mg
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $288/10mg
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $433/5mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $288/20mg

    Apigenin 7-O-methylglucuronide

    Apigenin 7-O-methylglucuronide
    Product Name Apigenin 7-O-methylglucuronide
    CAS No.: 53538-13-9
    Catalog No.: CFN98894
    Molecular Formula: C22H20O11
    Molecular Weight: 460.4 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Source: The herbs of Thymus serpyllum L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • SBRAS2016, 12
  • Antiviral Res.2013, 98(3):386-93
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Chem Biol Interact.2018, 283:59-74
  • Molecules.2020, 25(23):5556.
  • Molecules.2019, 24(4):E709
  • Agronomy2020, 10(10),1489
  • Planta Med.2018, 84(6-07):465-474
  • Universidade Estadual Paulista2017, 11449
  • Arch Pharm Res.2015, 38(6):1080-9
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Osteogenic agents Compound Library
  • Flavonoids Compound Library
  • Biological Activity
    Description: Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide which normalized collagen synthesis in OI cells may exert their effects through beta1-integrin-mediated signaling.
    In vitro:
    Mol Med Rep. 2010 May-Jun;3(3):537-41.
    Differential effect of flavonoids on glycosaminoglycan content and distribution in skin fibroblasts of patients with type I osteogenesis imperfecta.[Pubmed: 21472276]
    We recently reported that, in osteogenesis imperfecta (OI) type I with diminished type I collagen biosynthesis, flavonoids such as apigenin 7-O-glucuronide, Apigenin 7-O-methylglucuronide and pectolinarin normalized the level of collagen type I without affecting total protein synthesis. In addition to collagen, glycosaminoglycans (GAGs) play an important role in the formation of a functional supramolecular complex in the extracellular matrix, and any changes in their content and/or composition may be involved in the OI phenotype.
    METHODS AND RESULTS:
    We previously detected a marked increase in sulphated GAG content in the OI fibroblasts of more severely affected patients (OI types II and III). These alterations were more pronounced in medium than in cells. Although, in OI type I cells, the increase observed in medium was much smaller (approximately 1.5-fold), it resulted in an increase of approximately 3-fold of the GAG to collagen type I ratio. Therefore, in the potential pharmacotherapy of OI type I with flavonoids, their effect on GAG level may be of importance. In the OI cells, some of the tested flavonoids applied at a concentration of 30 µM affected GAG content in quite the opposite way than type I collagen. Aglicones inhibiting collagen synthesis caused a marked increase in GAG concentration in medium, in contrast to the flavonoid glycosides, which exerted a stimulatory effect on type I collagen synthesis, but had a different effect on GAG content and distribution.
    CONCLUSIONS:
    Among these, Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, and thus may potentially be used in OI type I pharmacotherapy in patients with normal GAG content. However, in patients with increased concentrations of GAG, pectolinarin, which decreases GAG content by approximately 40%, may be more beneficial.
    Apigenin 7-O-methylglucuronide Description
    Source: The herbs of Thymus serpyllum L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Dehydrojuncusol

    Catalog No: CFN95143
    CAS No: 117824-04-1
    Price: $318/5mg
    Physalin G

    Catalog No: CFN95104
    CAS No: 76045-38-0
    Price: $388/5mg
    2''-O-Galloylquercitrin

    Catalog No: CFN95041
    CAS No: 80229-08-9
    Price: $418/5mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $/mg
    Glycinol

    Catalog No: CFN95122
    CAS No: 69393-95-9
    Price: $398/5mg
    ent-16beta,17-dihydroxy-9(11)-kaur...

    Catalog No: CFN95172
    CAS No: 55483-24-4
    Price: $318/10mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Rhamnetin 3-galactoside

    Catalog No: CFN95116
    CAS No: 62858-07-5
    Price: $318/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.172 mL 10.8601 mL 21.7202 mL 43.4405 mL 54.3006 mL
    5 mM 0.4344 mL 2.172 mL 4.344 mL 8.6881 mL 10.8601 mL
    10 mM 0.2172 mL 1.086 mL 2.172 mL 4.344 mL 5.4301 mL
    50 mM 0.0434 mL 0.2172 mL 0.4344 mL 0.8688 mL 1.086 mL
    100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.4344 mL 0.543 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Cell Research:
    Int J Mol Med. 2007 Dec;20(6):889-95.
    Stimulation of collagen biosynthesis by flavonoid glycosides in skin fibroblasts of osteogenesis imperfecta type I and the potential mechanism of their action.[Pubmed: 17982699]
    The aim of the present study was to identify bioactive compounds stimulating collagen biosynthesis with potential for osteogenesis imperfecta (OI) type I pharmacological therapy.
    METHODS AND RESULTS:
    Of the compounds tested, apigenin glycosides 7-O-glucuronide, 7-O-methylglucuronide and pectolinarin at 30 microM were found to significantly induce collagen type I synthesis in OI fibroblasts without an effect on the overall protein synthesis. None of the compounds displayed any toxicity at that concentration. Secretion of collagen into media was not affected by apigenin 7-O-glucuronide and was slightly increased in cells treated with Apigenin 7-O-methylglucuronide and pectolinarin. Furthermore, procollagen secreted by treated cells underwent a more rapid processing into collagen as compared with control untreated cells. In addition, we elucidated the possible mechanism involved in their action. Stimulation of collagen biosynthesis was not due to an increase in cell proliferation, because no differences in DNA content between the compound-treated and untreated cells were observed. Since flavonoids are known as strong inhibitors of metalloproteinases degrading matrix proteins, the increased level of collagen could result from the inhibition of their activity. However, the compounds with a stimulatory effect on collagen synthesis did not influence the activities of collagenase type I, gelatinases A and B, and stromelysin. On the contrary, all compounds stimulated the activity of prolidase which catalyzes the final step of collagen degradation and plays an important role in collagen biosynthesis.
    CONCLUSIONS:
    Stimulation of collagen synthesis and prolidase activity by apigenin 7-O-glucuronide was accompanied by an increase in IGF-I receptor expression. In contrast, the compounds Apigenin 7-O-methylglucuronide and pectolinarin which normalized collagen synthesis in OI cells may exert their effects through beta1-integrin-mediated signaling.
    Germacrone

    Catalog No: CFN98133
    CAS No: 6902-91-6
    Price: $40/20mg
    3,6'-Disinapoyl sucrose

    Catalog No: CFN90578
    CAS No: 139891-98-8
    Price: $138/20mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $488/5mg
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $288/10mg
    Enmein

    Catalog No: CFN92435
    CAS No: 3776-39-4
    Price: $433/5mg
    Chrysosplenol D

    Catalog No: CFN99622
    CAS No: 14965-20-9
    Price: $268/10mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $288/20mg