Brassicasterol | CAS:474-67-9 | Manufacturer ChemFaces

Brassicasterol

ChemFaces products have been cited in many studies from excellent and top scientific journals

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Brassicasterol may be a relevant additional biomarker in Alzheimer's disease (AD).

In vivo:

Curr Gerontol Geriatr Res. 2012;2012:179318.

Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels.[Pubmed: 22649448]

Over the past 15 years, insights into sterol metabolism have improved our understanding of the relationship between lipids and common conditions such as atherosclerosis and Alzheimer's Disease (AD). A better understanding of sterol lipid metabolism in individuals with Down Syndrome (DS) may help elucidate how this population's unique metabolic characteristics influence their risks for atherosclerosis and AD.
METHODS AND RESULTS:
To revisit the question of whether sterol lipid parameters may be altered in DS subjects, we performed a pilot study to assess traditional serum sterol lipids and lipoproteins, as well as markers of sterol biosynthesis, metabolites, and plant sterols in 20 subjects with DS compared to age-matched controls.
CONCLUSIONS:
Here we report that the levels of nearly all lipids and lipoproteins examined are similar to control subjects, suggesting that trisomy 21 does not lead to pronounced general alterations in sterol lipid metabolism. However, the levels of serum Brassicasterol were markedly reduced in DS subjects.

Acta Psychiatr. Scand. ,2011,124(3):184-92.

The plant sterol brassicasterol as additional CSF biomarker in Alzheimer's disease.[Reference: WebLink]

METHODS AND RESULTS:
Plant sterols (sitosterol, campesterol, stigmasterol and Brassicasterol) are solely dietary-derivable sterols that are structurally very similar to cholesterol. In contrast to peripheral cholesterol, plant sterols can cross the blood-brain barrier and accumulate within mammalian brain.
CONCLUSIONS:
As an impaired function of the cerebrospinal fluid (CSF)-blood barrier is linked to neurodegenerative disorders, i.e. Alzheimer's disease (AD), we investigated whether this results in altered plant sterol concentrations in CSF.

Brassicasterol Description

Source:	The seeds of Brassica campestris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Brassicasterol
Price:	$318 / 5mg
CAS No.:	474-67-9
Catalog No.:	CFN90471
Molecular Formula:	C₂₈H₄₆O
Molecular Weight:	398.66 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The seeds of Brassica campestris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Markers Compound Library Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5084 mL	12.542 mL	25.084 mL	50.1681 mL	62.7101 mL
5 mM	0.5017 mL	2.5084 mL	5.0168 mL	10.0336 mL	12.542 mL
10 mM	0.2508 mL	1.2542 mL	2.5084 mL	5.0168 mL	6.271 mL
50 mM	0.0502 mL	0.2508 mL	0.5017 mL	1.0034 mL	1.2542 mL
100 mM	0.0251 mL	0.1254 mL	0.2508 mL	0.5017 mL	0.6271 mL

CFN92204	Campesterol	474-62-4	400.7	C₂₈H₄₈O
CFN90471	Brassicasterol	474-67-9	398.66	C₂₈H₄₆O
CFN98267	Stellasterol	2465-11-4	398.7	C₂₈H₄₆O
CFN96785	Ergosta-7,22-dien-3-one	32507-77-0	396.65	C₂₈H₄₄O
CFN98980	Ergosterol	57-87-4	396.7	C₂₈H₄₄O
CFN89026	Ergosterol glucoside	130155-33-8	558.8	C₃₄H₅₄O₆
CFN98357	Ergosta-5,24(28)-diene-3,7,16-triol	289054-34-8	430.7	C₂₈H₄₆O₃
CFN99665	3-beta-Hydroxyergost-5-en-7-one	156767-69-0	414.7	C₂₈H₄₆O₂
CFN99889	Ergosta-4,6,8(14),22-tetraen-3-one	19254-69-4	392.6	C₂₈H₄₀O
CFN98825	Cerevisterol	516-37-0	430.7	C₂₈H₄₆O₃