Britannilactone | CAS:33620-72-3 | Manufacturer ChemFaces

Britannilactone

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $94.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Britannilactone significantly reduces melanin production in a dose-dependent manner with the IC50 value of 15.5 uM.

In vitro:

Arch Pharm Res. 2014 May;37(5):567-74.

Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells.[Pubmed: 24346861]

During the course of screens to identify anti-melanogenic agents from natural resources, we found that the methanol extract of the dried flower of Inula britannica L. inhibited melanin synthesis in cultured melanoma cells stimulated with 3-isobutyl-1-methylxanthine (IBMX).
METHODS AND RESULTS:
A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpenes, 1-O-acetylBritannilactone (1), Britannilactone (2) and neoBritannilactone B (3). Compounds 1 and 2 significantly reduced melanin production in a dose-dependent manner with IC50 values of 13.3 and 15.5 μM, respectively, whereas compound 3 was found to be cytotoxic. Compound 1 also inhibited the tyrosinase activity only in cell based-systems. Western blot analysis indicated that compound 1 inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2.
CONCLUSIONS:
These results demonstrated that compound 1, a major sesquiterpene from the flowers of I. britannica, exhibited anti-melanogenic activity by suppression of tyrosinase expression via ERK and Akt signaling. Taken together, our results suggest that these compounds may act as potent natural skin-lightening agents.

Britannilactone Description

Source:	The herbs of Inula japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Britannilactone
Price:	$318 / 20mg
CAS No.:	33620-72-3
Catalog No.:	CFN92601
Molecular Formula:	C₁₅H₂₂O₄
Molecular Weight:	266.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Inula japonica Thunb.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-melanogenic Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7552 mL	18.7758 mL	37.5516 mL	75.1033 mL	93.8791 mL
5 mM	0.751 mL	3.7552 mL	7.5103 mL	15.0207 mL	18.7758 mL
10 mM	0.3755 mL	1.8776 mL	3.7552 mL	7.5103 mL	9.3879 mL
50 mM	0.0751 mL	0.3755 mL	0.751 mL	1.5021 mL	1.8776 mL
100 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.751 mL	0.9388 mL

CFN99825	Carabrone	1748-81-8	248.3	C₁₅H₂₀O₃
CFN92649	Dihydrocurcumenone	142717-57-5	236.4	C₁₅H₂₄O₂
CFN92026	Curcumenone	100347-96-4	234.3	C₁₅H₂₂O₂
CFN92653	Curcumadionol	1235984-45-8	248.3	C₁₅H₂₀O₃
CFN97170	4-Oxobedfordiaic acid	68799-38-2	250.3	C₁₅H₂₂O₃
CFN99095	3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide	1093207-99-8	224.3	C₁₃H₂₀O₃
CFN98315	Xanthatin	26791-73-1	246.3	C₁₅H₁₈O₃
CFN89507	8-Epixanthatin	30890-35-8	246.30	C₁₅H₁₈O₃
CFN89001	6alpha-Hydroxytomentosin	1232676-22-0	264.32	C₁₅H₂₀O₄
CFN99644	Xanthinin	153483-31-9	306.4	C₁₇H₂₂O₅