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Chicanine
Chicanine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Chicanine
Price: $313 / 5mg
CAS No.: 78919-28-5
Catalog No.: CFN90914
Molecular Formula: C20H22O5
Molecular Weight: 342.39 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The fruits of Osmanthus fragrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $227.8 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
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  • Vin?a Institute of Nuclear Scie... (Serbia)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Chicanine also has good anti-proliferation (IC₅₀=44.2uM) on prostate cells and antioxidant activities (IC₅₀=26.0 uM,) with no significant toxic effects on normal cells.
Targets: NO | PGE | NF-kB | COX | TNF-α | NOS | ERK | p38MAPK | TLR | IkB | IKK
In vitro:
Eur J Pharmacol. 2014 Feb 5;724:168-74.
Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways[Pubmed: 24361309 ]
Schisandra chinensis Baill is a Chinese traditional medicine with multiple pharmacological activities.
METHODS AND RESULTS:
In this study, Chicanine, one of the major lignan compounds of S. chinesis, was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in murine macrophages (RAW 264.7 cells). Chicanine was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO) and Prostaglandin E (2) (PGE2) production and nuclear factor-κB (NF-κB) signaling in LPS-stimulated RAW 264.7 cells with no cytotoxic effects. Treatment of RAW 264.7 cells with Chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFα, IL-1β, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK 1/2), and also IκB-α phosphorylation.
CONCLUSIONS:
These results indicated that anti-inflammatory actions of Chicanine in macrophages involved inhibition of LPS-induced TLR4-IκBα/MAPK/ERK signaling pathways.
Industrial Crops & Products, 2013, 50(4):690-693.
Antioxidant and anti-proliferative activities of five compounds from Schisandra chinensis fruit.[Reference: WebLink]
Schisandra chinensis fruit has been used as functional foods and traditional Chinese medicine for thousands years. In order to illustrate the main active components, one triterpenoid and four lignan compounds were isolated from Schisandra chinensis.
METHODS AND RESULTS:
The antioxidant and anti-proliferative activities of the five compounds and extract were evaluated by DPPH radical-scavenging assay and MTT assay on prostate cancer cells PC3. The structures of the compounds were fully characterized, which were d-epigalbacin, machilin G, Chicanine, anwulignan, and epi-anwuweizic acid, respectively. Activity results showed that epi-anwuweizic acid had the highest cytotoxic activity on prostate cells (IC₅₀=36.5μM) but lower antioxidant activities. Chicanine had good anti-proliferation (IC₅₀=44.2μM) and antioxidant activities (IC₅₀=26.0μM,) with no significant toxic effects on normal cells.
CONCLUSIONS:
The results suggested that there were lignan and triterpenoid compounds in Schisandra chinensis to have biological activities on diseases associated with aging and cancer.
Chicanine Description
Source: The fruits of Osmanthus fragrans.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9206 mL 14.6032 mL 29.2065 mL 58.4129 mL 73.0162 mL
5 mM 0.5841 mL 2.9206 mL 5.8413 mL 11.6826 mL 14.6032 mL
10 mM 0.2921 mL 1.4603 mL 2.9206 mL 5.8413 mL 7.3016 mL
50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.1683 mL 1.4603 mL
100 mM 0.0292 mL 0.146 mL 0.2921 mL 0.5841 mL 0.7302 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(24):4329-34.
Chemical constituents of Osmanthus fragrans fruits.[Pubmed: 24791540]
By Silica gel, Sephadex LH-20 and other materials for isolation and purification and by physicochemical methods and spectral analysis for structural identification, 23 compounds were isolated and identified from ethyl acetate portion of alcohol extract solution of Osmanthus fragrans fruits.
METHODS AND RESULTS:
Their structures were identified as nicotinamide (1), D-allitol (2), 5-hydroxymethyl-2-furancarboxaldehyde (3), acetyloleanolic acid (4), benzoic acid (5), ergosta-7,22-dien-3-one (6), beta-sitosterol (7), borreriagenin (8), cerevistero (9), c-veratroylglycol (10), methyl-2-O-beta-glucopyranosylbenzoate (11), 3', 7-dihydroxy-4'-methoxyisoflavon (12), umbelliferone (13), caffeic acid methyl ester (14), oleanolic acid (15), (-) -Chicanine (16), dillapiol (17), 3beta,5alpha, 9alpha-trihydroxyergosta-7-22-dien-6-one (18), 2alpha-hydroxy-oleanolic acid (19), betulinic acid (20), betulin (21), 3, 3'-bisdemethylpinoresinol (22), and lupeol (23).
CONCLUSIONS:
All compounds were isolated from the osmanthus fruit for the first time. Except for compounds 4, 7, 15, 19, 23, the rest ones were isolated from the this plant for the first time.
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