Cinobufotenine | CAS:60657-23-0 | Manufacturer ChemFaces

Cinobufotenine

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Description:

Cinobufotenine is a potent stimulant of parasympathetic ganglia and its effect are competitively antagonized by hexamethonium.

In vitro:

Br J Pharmacol. 1980 Aug;69(4):597-600.

A comparison of cinobufotenine (the quaternary derivative of 5-HT) and some related compounds with coryneine (the quaternary derivative of dopamine) on the frog rectus, guinea-pig ileum and rat fundus strip preparations.[Pubmed: 6449223 ]

METHODS AND RESULTS:
1 Coryneine is 2.7 times as active as Cinobufotenine on the frog rectus but on the guinea-pig ileum Cinobufotenine is 1.5 times as active as coryneine. Cinobufotenine is a potent stimulant of parasympathetic ganglia and its effect are competitively antagonized by hexamethonium. 2 The effects of pH on activity relative to a standard whose ionisation is constant (Me4+N or the trimethylammonium analogue of tryptamine) are consistent with the phenate form being weaker than the phenolic form but the changes are smaller than with coryneine because Cinobufotenine is a weaker acid.
CONCLUSIONS:
3 The hydroxyl group makes a large contribution to activity. Cinobufotenine is 9 times as active as the analogue without a hydroxyl on the frog rectus and 12 times as active as it on the ileum. The 5-methoxy analogue is an antagonist on the frog rectus and a very weak partial agonist on the ileum. 4 Cinobufotenine and the quaternary derivative of tryptamine have less than one-thousandth of the activity of 5-hydroxytryptamine on the rat fundus strip.

Cinobufotenine Description

Source:	The glandular body of Bufo bufo gargarizans Cantor.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cinobufotenine
Price:	$338 / 10mg
CAS No.:	60657-23-0
Catalog No.:	CFN91166
Molecular Formula:	C₁₃H₁₉N₂O
Molecular Weight:	219.3 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The glandular body of Bufo bufo gargarizans Cantor.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.56 mL	22.7998 mL	45.5996 mL	91.1993 mL	113.9991 mL
5 mM	0.912 mL	4.56 mL	9.1199 mL	18.2399 mL	22.7998 mL
10 mM	0.456 mL	2.28 mL	4.56 mL	9.1199 mL	11.3999 mL
50 mM	0.0912 mL	0.456 mL	0.912 mL	1.824 mL	2.28 mL
100 mM	0.0456 mL	0.228 mL	0.456 mL	0.912 mL	1.14 mL

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CFN92785	1,2,3,4-Tetrahydronorharman-1-one	17952-82-8	186.2	C₁₁H₁₀N₂O
CFN95323	Cuscutamine	122170-93-8	270.3	C₁₅H₁₄N₂O₃
CFN95796	MTCA(1-Methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid)	5470-37-1	230.3	C₁₃H₁₄N₂O₂
CFN96036	1-Methoxyindole-3-carboxylic acid	91913-76-7	191.2	C₁₀H₉NO₃
CFN96052	Caulilexin C	30536-48-2	186.2	C₁₁H₁₀N₂O
CFN91557	N-Methylserotonin	1134-01-6	190.2	C₁₁H₁₄N₂O
CFN91430	Bufobutanoic acid	74010-65-4	276.3	C₁₄H₁₆N₂O₄
CFN98111	Gramine	87-52-5	174.25	C₁₁H₁₄N₂
CFN91165	Bufotenine	487-93-4	204.3	C₁₂H₁₆N₂O