Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Deoxyvasicinone
    Information
    CAS No. 530-53-0 Price
    Catalog No.CFN98882Purity>=98%
    Molecular Weight186.2 Type of CompoundAlkaloids
    FormulaC11H10N2OPhysical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Instituto de Investigaciones Ag... (Chile)
  • Sanford Burnham Prebys Medical ... (USA)
  • Periyar University (India)
  • University of Liège (Belgium)
  • Research Unit Molecular Epigene... (Germany)
  • Kamphaengphet Rajabhat University (Thailand)
  • Lund University (Sweden)
  • Seoul National University (Korea)
  • University of Wisconsin-Madison (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
  • Package
    Featured Products
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    3,4-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90856
    CAS No: 114637-83-1
    Price: $388/5mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $413/5mg
    Dihydromorin

    Catalog No: CFN99854
    CAS No: 18422-83-8
    Price: $403/5mg
    Polygalaxanthone III

    Catalog No: CFN90208
    CAS No: 162857-78-5
    Price: $138/20mg

    Deoxyvasicinone

    Deoxyvasicinone
    Product Name Deoxyvasicinone
    CAS No.: 530-53-0
    Catalog No.: CFN98882
    Molecular Formula: C11H10N2O
    Molecular Weight: 186.2 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The herbs of Galium aparine L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Natural Product Communications2020, doi: 10.1177.
  • Inflammation.2020, 43(5):1716-1728.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Nutr Res Pract2019, 13:e45
  • Molecules.2016, 21(6)
  • Molecules.2019, 24(19):E3417
  • Pharm Biol.2016, 54(7):1255-62
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Drug Chem Toxicol.2020, 1-12.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Precursors Compound Library
  • Alkaloids Compound Library
  • Biological Activity
    Description: Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.
    In vitro:
    Methods. 2015 Jan;71:71-6.
    Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.[Pubmed: 25196325]
    NEDD8-activating enzyme (NAE) controls the specific degradation of proteins regulated by cullin-RING ubiquitin E3 ligases, and has been considered as an attractive molecular target for the development of drugs against cancer.
    METHODS AND RESULTS:
    A pharmacophore model constructed from a training set of Deoxyvasicinone derivatives was used to screen 376 compounds from an analogue database. From the initial screening, the valine-linked Deoxyvasicinone derivative 9 and the N-isopropyl-linked Deoxyvasicinone derivative 10 emerged as the top scoring candidates. Compounds 9 and 10 showed micromolar potencies in both cell-free and cell-based systems, with selectivity for NAE over the related enzymes SAE and UAE. Molecular modelling analysis suggested that 9 and 10 may inhibit NAE by blocking the ATP-binding domain.
    CONCLUSIONS:
    Thus, these Deoxyvasicinone derivatives could be considered as promising lead molecules for the development of more potent inhibitors of NAE.
    Deoxyvasicinone Description
    Source: The herbs of Galium aparine L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Batatasin III

    Catalog No: CFN92689
    CAS No: 56684-87-8
    Price: $238/5mg
    Ganoderiol F

    Catalog No: CFN99244
    CAS No: 114567-47-4
    Price: $398/5mg
    3-O-[5'''-O-feruloyl-beta-D-apiofu...

    Catalog No: CFN95154
    CAS No: 148210-00-8
    Price: $413/5mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Eudesmin

    Catalog No: CFN96266
    CAS No: 526-06-7
    Price: $188/20mg
    6'-Feruloylnodakenin

    Catalog No: CFN95202
    CAS No: 131623-14-8
    Price: $318/10mg
    Withaferin A

    Catalog No: CFN91895
    CAS No: 5119-48-2
    Price: $298/20mg
    1,3,6-Trihydroxy-2-methylanthraqui...

    Catalog No: CFN95096
    CAS No: 87686-88-2
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3706 mL 26.8528 mL 53.7057 mL 107.4114 mL 134.2642 mL
    5 mM 1.0741 mL 5.3706 mL 10.7411 mL 21.4823 mL 26.8528 mL
    10 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
    50 mM 0.1074 mL 0.5371 mL 1.0741 mL 2.1482 mL 2.6853 mL
    100 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $413/5mg
    3,4-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90856
    CAS No: 114637-83-1
    Price: $388/5mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $413/5mg
    Dihydromorin

    Catalog No: CFN99854
    CAS No: 18422-83-8
    Price: $403/5mg
    Polygalaxanthone III

    Catalog No: CFN90208
    CAS No: 162857-78-5
    Price: $138/20mg