Science | Nature | Cell | View More
Natural Products
Deoxyvasicinone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Deoxyvasicinone
Price:
CAS No.: 530-53-0
Catalog No.: CFN98882
Molecular Formula: C11H10N2O
Molecular Weight: 186.2 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Galium aparine L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Wuerzburg (Germany)
  • Almansora University (Egypt)
  • Universita' Degli Studi Di Cagl... (Italy)
  • Universidad Veracuzana (Mexico)
  • Korea Food Research Institute(K... (Korea)
  • Universidade de Franca (Brazil)
  • University of Cincinnati (USA)
  • Indian Institute of Science (India)
  • Auburn University (USA)
  • Amity University (India)
  • Korea Institute of Oriental Med... (Korea)
  • More...
Package
Featured Products
Triptolide

Catalog No: CFN99196
CAS No: 38748-32-2
Price: $118/20mg
Delta 7-avenasterol

Catalog No: CFN92240
CAS No: 23290-26-8
Price: $ / mg
Isocorynoxeine

Catalog No: CFN98155
CAS No: 51014-29-0
Price: $128/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg
(E)-6-O-(p-coumaroyl)scandoside me...

Catalog No: CFN95192
CAS No: 83946-90-1
Price: $218/10mg
Riboflavine

Catalog No: CFN90067
CAS No: 83-88-5
Price: $30/20mg
Cimifugin

Catalog No: CFN98612
CAS No: 37921-38-3
Price: $60/20mg
2''-O-Rhamnosylicariside II

Catalog No: CFN92551
CAS No: 135293-13-9
Price: $288/10mg
Zingerone

Catalog No: CFN99702
CAS No: 122-48-5
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.
In vitro:
Methods. 2015 Jan;71:71-6.
Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.[Pubmed: 25196325]
NEDD8-activating enzyme (NAE) controls the specific degradation of proteins regulated by cullin-RING ubiquitin E3 ligases, and has been considered as an attractive molecular target for the development of drugs against cancer.
METHODS AND RESULTS:
A pharmacophore model constructed from a training set of Deoxyvasicinone derivatives was used to screen 376 compounds from an analogue database. From the initial screening, the valine-linked Deoxyvasicinone derivative 9 and the N-isopropyl-linked Deoxyvasicinone derivative 10 emerged as the top scoring candidates. Compounds 9 and 10 showed micromolar potencies in both cell-free and cell-based systems, with selectivity for NAE over the related enzymes SAE and UAE. Molecular modelling analysis suggested that 9 and 10 may inhibit NAE by blocking the ATP-binding domain.
CONCLUSIONS:
Thus, these Deoxyvasicinone derivatives could be considered as promising lead molecules for the development of more potent inhibitors of NAE.
Deoxyvasicinone Description
Source: The herbs of Galium aparine L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Barbaloin-related compound A

Catalog No: CFN95453
CAS No: 473225-21-7
Price: $318/5mg
Andrographidine A

Catalog No: CFN95210
CAS No: 113963-37-4
Price: $318/10mg
Lyciumamide B

Catalog No: CFN95286
CAS No: 1647111-41-8
Price: $318/5mg
Silychristin B

Catalog No: CFN95160
CAS No: 879325-58-3
Price: $318/5mg
2,3-Dehydrosilychristin

Catalog No: CFN95370
CAS No: 57499-41-9
Price: $318/5mg
(1E)-3-methoxy-8,12-epoxygermacra-...

Catalog No: CFN95219
CAS No: 1393342-06-7
Price: $413/5mg
Neoarctin B

Catalog No: CFN95243
CAS No: 155969-67-8
Price: $318/10mg
Dioscoreside C

Catalog No: CFN95345
CAS No:
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.3706 mL 26.8528 mL 53.7057 mL 107.4114 mL 134.2642 mL
5 mM 1.0741 mL 5.3706 mL 10.7411 mL 21.4823 mL 26.8528 mL
10 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
50 mM 0.1074 mL 0.5371 mL 1.0741 mL 2.1482 mL 2.6853 mL
100 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Triptolide

Catalog No: CFN99196
CAS No: 38748-32-2
Price: $118/20mg
Delta 7-avenasterol

Catalog No: CFN92240
CAS No: 23290-26-8
Price: $ / mg
Isocorynoxeine

Catalog No: CFN98155
CAS No: 51014-29-0
Price: $128/20mg
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
D-(+)-Glucose

Catalog No: CFN99769
CAS No: 50-99-7
Price: $30/20mg
(E)-6-O-(p-coumaroyl)scandoside me...

Catalog No: CFN95192
CAS No: 83946-90-1
Price: $218/10mg
Riboflavine

Catalog No: CFN90067
CAS No: 83-88-5
Price: $30/20mg
Cimifugin

Catalog No: CFN98612
CAS No: 37921-38-3
Price: $60/20mg
2''-O-Rhamnosylicariside II

Catalog No: CFN92551
CAS No: 135293-13-9
Price: $288/10mg
Zingerone

Catalog No: CFN99702
CAS No: 122-48-5
Price: $30/20mg
Tags: buy Deoxyvasicinone | Deoxyvasicinone supplier | purchase Deoxyvasicinone | Deoxyvasicinone cost | Deoxyvasicinone manufacturer | order Deoxyvasicinone | Deoxyvasicinone distributor