Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Savinin
    Savinin
    Information
    CAS No. 493-95-8 Price
    Catalog No.CFN98786Purity>=98%
    Molecular Weight352.3 Type of CompoundLignans
    FormulaC20H16O6Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Pennsylvania State University (USA)
  • University of the Basque Country (Spain)
  • Copenhagen University (Denmark)
  • Universitas Airlangga (Indonesia)
  • Siksha O Anusandhan University (India)
  • University of Hertfordshire (United Kingdom)
  • Universidad de Ciencias y Artes... (Mexico)
  • Medical University of Gdansk (Poland)
  • Chiang Mai University (Thailand)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • Universidade Federal de Santa C... (Brazil)
  • More...
  • Package
    Featured Products
    Trifolirhizin

    Catalog No: CFN97160
    CAS No: 6807-83-6
    Price: $128/20mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    13-Hydroxylupanine

    Catalog No: CFN92232
    CAS No: 15358-48-2
    Price: $513/5mg
    Tangeretin

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $30/20mg
    Decuroside I

    Catalog No: CFN95004
    CAS No: 96638-79-8
    Price: $318/5mg

    Savinin

    Savinin
    Product Name Savinin
    CAS No.: 493-95-8
    Catalog No.: CFN98786
    Molecular Formula: C20H16O6
    Molecular Weight: 352.3 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Targets: TNF-伪
    Source: The heartwoods of Pterocarpus santalinus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Inflammation.2015, 38(4):1502-16
  • TCI CO.2019, US20190151281A1
  • Research Square2020, doi: 10.21203.
  • J Separation Science & Technology2016, 51:1579-1588
  • Food Chem Toxicol.2020, 135:110863
  • Appl. Sci.2020, 10(23), 8729
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Agronomy2020, 10(10),1489
  • Oncotarget.2017, 8(64):108006-108019
  • BMC Complement Altern Med.2016, 16:213
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Insecticides Compound Library
  • Lignans Compound Library
  • TNF-α Inhibitor Library
  • Biological Activity
    Description: Savinin has antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. Savinin also exhibits potent spermicidal activity and significant insecticidal activity.
    Targets: TNF-α
    In vitro:
    Phytochemistry. 2001 Apr;56(8):857-61.
    Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.[Pubmed: 11324918 ]

    METHODS AND RESULTS:
    Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, Savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine.
    CONCLUSIONS:
    8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both Savinin and sesamin exhibited significant insecticidal activity.
    Savinin Description
    Source: The heartwoods of Pterocarpus santalinus
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Platycogenin A

    Catalog No: CFN95240
    CAS No: 1459719-53-9
    Price: $388/5mg
    (E)-6-O-(p-coumaroyl)scandoside me...

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg
    4-Hydroxybenzoyl choline

    Catalog No: CFN95158
    CAS No: 5094-31-5
    Price: $318/20mg
    (3E,5E,11E)-tridecatriene-7,9-diyn...

    Catalog No: CFN95191
    CAS No: N/A
    Price: $318/5mg
    (R)-O-isobutyroyllomatin

    Catalog No: CFN95250
    CAS No: 440094-38-2
    Price: $413/5mg
    New compound 4

    Catalog No: CFN95185
    CAS No: N/A
    Price: $368/5mg
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $100/20mg
    9-Octadecenedioic acid

    Catalog No: CFN95301
    CAS No: 4494-16-0
    Price: $218/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8385 mL 14.1924 mL 28.3849 mL 56.7698 mL 70.9622 mL
    5 mM 0.5677 mL 2.8385 mL 5.677 mL 11.354 mL 14.1924 mL
    10 mM 0.2838 mL 1.4192 mL 2.8385 mL 5.677 mL 7.0962 mL
    50 mM 0.0568 mL 0.2838 mL 0.5677 mL 1.1354 mL 1.4192 mL
    100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5677 mL 0.7096 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Biol Pharm Bull. 2001 Feb;24(2):167-71.
    Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.[Pubmed: 11217086]

    METHODS AND RESULTS:
    Two lignans were isolated from the heartwood of Pterocarpus santalinus by activity-guided fractionation and investigated for their biological properties and molecular mechanism of action. On the basis of their spectroscopic data, these compounds were identified as Savinin (1) and calocedrin (2), dibenzyl butyrolactone-type lignan compounds having an alpha-arylidene gamma-lactone structure. These lignans significantly inhibited tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. The molecular inhibitory mechanism of compound 1 was confirmed to be mediated by the non-polar butyrolactone ring, according to a structure-relationship study with structurally related and unrelated compounds, such as arctigenin (a dibenzyl butyrolactone type lignan), eudesmin (a furofuran type lignan), isolariciresinol (a dibenzylbutane type lignan), and cynaropicrin (a sesquiterpene lactone).
    CONCLUSIONS:
    The results suggest that Savinin may act as an active principle in the reported biological activities of P. santalinus, such as antiinflammatory effect, by mediation of the butyrolactone ring as a valuable pharmacophore.
    Trifolirhizin

    Catalog No: CFN97160
    CAS No: 6807-83-6
    Price: $128/20mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    7-Methoxyneochamaejasmine A

    Catalog No: CFN92156
    CAS No: 402828-38-0
    Price: $433/5mg
    13-Hydroxylupanine

    Catalog No: CFN92232
    CAS No: 15358-48-2
    Price: $513/5mg
    Tangeretin

    Catalog No: CFN90240
    CAS No: 481-53-8
    Price: $30/20mg
    Decuroside I

    Catalog No: CFN95004
    CAS No: 96638-79-8
    Price: $318/5mg