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Triumbelletin
Triumbelletin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Triumbelletin
Price:
CAS No.: 131559-54-1
Catalog No.: CFN96473
Molecular Formula: C27H14O9
Molecular Weight: 482.39 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Wikstroemia indica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Triumbelletin is a natural product from Wikstroemia indica.
In vitro:
Natural Product Research & Development, 2014 , 26 (6) :851-5.
Phenolic Constituents from Rhizome of Wikstroemia indica and Their Anti-tumor Activity[Reference: WebLink]

METHODS AND RESULTS:
Seventeen phenolic constituents were isolated from the rhizome of Wikstroemia indica using a combination of various chromatographic methods. Their structures were elucidated and identified as wikstromol( 1),matairesinol( 2),syringaresinol( 3),pinoresinol( 4),isolariciresinol( 5),ciwujiatone( 6),isorhamnetin-3-O-robinobioside( 7),wikstaiwanone A( 8),wikstaiwanone B( 9),kaempferol( 10),rutin( 11),daphnoretin( 12),Triumbelletin( 13),alnusdiol( 14),aloe-emodin-8-O-β-D-glucoside( 15),chlorogenic acid( 16) and p-hydroxybenzoic acid( 17) by physicochemical properties and spectral data including NMR and MS. Compounds 3-9 and 13-16 were isolated from this plant for the first time.
CONCLUSIONS:
The anti-tumor tests showed compounds 1-4,6-9 exhibited different activities against colon cancer cell lines SW480 and SW620,in which compound 6 showed most significant activities against the two cell lines.
Triumbelletin Description
Source: The herbs of Wikstroemia indica
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.073 mL 10.3651 mL 20.7301 mL 41.4602 mL 51.8253 mL
5 mM 0.4146 mL 2.073 mL 4.146 mL 8.292 mL 10.3651 mL
10 mM 0.2073 mL 1.0365 mL 2.073 mL 4.146 mL 5.1825 mL
50 mM 0.0415 mL 0.2073 mL 0.4146 mL 0.8292 mL 1.0365 mL
100 mM 0.0207 mL 0.1037 mL 0.2073 mL 0.4146 mL 0.5183 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Sep Sci. 2015 Jun;38(12):2093-100.
Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.[Pubmed: 25866087]

METHODS AND RESULTS:
A sensitive, rapid and simple ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method was developed to determine seven constituents (umbelliferone, apigenin, Triumbelletin, daphnoretin, arctigenin, genkwanin and emodin) in Wikstroemia indica (L.) C. A. Mey. The chromatographic analysis was performed on an ACQUITY UPLC® BEH C18 column (2.1 × 50 mm, 1.7 μm) by gradient elution with the mobile phase of 0.05% formic acid aqueous solution (A) and acetonitrile (B).
CONCLUSIONS:
Multiple reaction monitoring mode with positive and negative electrospray ionization interface was carried out to detect the components. This method was validated in terms of specificity, linearity, accuracy, precision and stability.
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