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3. Inhibitors
trans-Aconitic acid
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $7.0 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Cancers (Basel).2021, 13(17):4327.Pharmaceuticals (Basel)....2021...Molecules.2019, 24(10):E1930Oncol Rep.2021, 46(1):143.J Chromatogr Sci.2015, 53(5):824-9Food Research2021, 5(1):65-71J Ethnopharmacol.2017, 198:87-90Molecules. 2013, 18(11):14105-21
Appl. Sci. 2021, 11(22), 10552Int J Mol Sci.2017, 19(1)Pharmaceutics.2021, 13(2):187. Biol Pharm Bull.2021, 44(12):1891-1893.BMB Rep.2018, 51(5):249-254Biotechnol Bioeng....2020...J. Soc. Cosmet. Sci. Korea2016, 163-171Pharm Biol.2016, 54(7):1255-62
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trans-Aconitic acid
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Mol Pharm.2017, 14(9):3164-3177Journal of Third Military Medical University2019, 41(2):110-115Food Research2021, 5(1):65-71Scientific World Journal.2014, 2014:654193Evid Based Complement Alternat Med.2016, 2016:1739760Korean J. Medicinal Crop Sci.2021, 29(1):45-50.Toxicol Mech Methods.2021, 1-12.Journal of Ginseng Research2019, 10.1016Front Microbiol.2020, 11:583594.J of L. Chroma.&Related Tech2017, 252-258
Related Screening Libraries
| Description: |
Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.Trans-aconitic acid has antileishmanial activity ,the diesters of TAA as potential useful derivatives for the management of rheumatoid arthritis and other inflammatory diseases. |
| Targets: |
Antifection |
| In vitro: |
| Plant Physiology & Biochemistry, 2018, 132:490-496. | | Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.[Reference: WebLink] | Grasses producing trans-Aconitic acid, a geometric isomer of cis-aconitic acid, are often used in Glycine max rotation systems. However, the effects of trans-Aconitic acid on Glycine max are unknown.
METHODS AND RESULTS:
We conducted a hydroponic experiment to evaluate the effects of 2.5–10 mM trans-Aconitic acid on Glycine max growth and photosynthesis. The results revealed that the enhanced H2O2 production in the roots increased the membrane permeability and reduced the water uptake. These effects culminated with a reduced stomatal conductance (gs), which seems to be the main cause for a decreased photosynthetic rate (A). Due to low gs, the limited CO2 assimilation may have overexcited the photosystems, as indicated by the high production of H2O2 in leaves. After 96 h of incubation, and due to H2O2-induced damage to photosystems, a probable non-stomatal limitation for photosynthesis contributed to reducing A. This is corroborated by the significant decrease in the quantum yield of electron flow through photosystem II in vivo (ΦPSII) and the chlorophyll content.
CONCLUSIONS:
Taken together, the damage to the root system and photosynthetic apparatus caused by trans-Aconitic acid significantly reduced the Glycine max plant growth. |
|
| In vivo: |
| Biomedicine & Pharmacotherapy, 2018, 99:87-95. | | Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis.[Reference: WebLink] | trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. Esterification was explored as a strategy to increase lipophilicity and biopharmaceutical properties of TAA, a highly polar tricarboxylic acid. We herein report the synthesis of TAA esters via Fischer esterification with ethanol, n-butanol and n-octanol.
METHODS AND RESULTS:
The reaction kinetics was investigated to produce mono-, di- and tri- derivatives. Mono- and diesters of TAA were obtained as a mixture of positional isomers, whereas the triesters were recovered as pure compounds. The obtained esters were screened in a model of acute arthritis induced by the injection of LPS in the knee joint of Swiss mice. The diesters were the most active compounds, regardless of the alcohol employed in the reaction, whereas bioactivity of the derivatives improved by increasing the length of the aliphatic chain of the alcohol employed in esterification. In general, the esters showed higher potency than TAA. When administered orally to mice at doses of 0.017-172.3 μmol/Kg, the diethyl, di-n-butyl and di-n-octyl esters of TAA reduced the cellular infiltration into the knee joint, especially of neutrophils.
CONCLUSIONS:
The study identified diesters of TAA as potential useful derivatives for the management of rheumatoid arthritis and other inflammatory diseases. |
|
trans-Aconitic acid Description
| Source: |
The herbs of Asarum europaeum L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
5.7438 mL |
28.7191 mL |
57.4383 mL |
114.8765 mL |
143.5956 mL |
| 5 mM |
1.1488 mL |
5.7438 mL |
11.4877 mL |
22.9753 mL |
28.7191 mL |
| 10 mM |
0.5744 mL |
2.8719 mL |
5.7438 mL |
11.4877 mL |
14.3596 mL |
| 50 mM |
0.1149 mL |
0.5744 mL |
1.1488 mL |
2.2975 mL |
2.8719 mL |
| 100 mM |
0.0574 mL |
0.2872 mL |
0.5744 mL |
1.1488 mL |
1.436 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Animal Research: |
| Biochemical medicine and metabolic biology, 1989, 42(3):171-178. | | Evaluation of antileishmanial activity of trans-aconitic acid.[Reference: WebLink] |
METHODS AND RESULTS:
TAA(trans-Aconitic acid), an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote form in vitro was also inhibited by 2 mm TAA. TAA also reduced multiplication of the parasite in macrophage culture.
CONCLUSIONS:
In the hamster model of leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day. |
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