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    Natural Products
    trans-Aconitic acid
    trans-Aconitic acid
    Information
    CAS No. 4023-65-8 Price $30 / 20 mg
    Catalog No.CFN70357Purity>=98%
    Molecular Weight174.1Type of CompoundMiscellaneous
    FormulaC6H6O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
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    trans-Aconitic acid

    trans-Aconitic acid
    Product Name trans-Aconitic acid
    CAS No.: 4023-65-8
    Catalog No.: CFN70357
    Molecular Formula: C6H6O6
    Molecular Weight: 174.1 g/mol
    Purity: >=98%
    Type of Compound: Miscellaneous
    Physical Desc.: Powder
    Targets: Antifection
    Source: The herbs of Asarum europaeum L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20 mg
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Miscellaneous Compound Library
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  • Biological Activity
    Description: Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.Trans-aconitic acid has antileishmanial activity ,the diesters of TAA as potential useful derivatives for the management of rheumatoid arthritis and other inflammatory diseases.
    Targets: Antifection
    In vitro:
    Plant Physiology & Biochemistry, 2018, 132:490-496.
    Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max.[Reference: WebLink]
    Grasses producing trans-Aconitic acid, a geometric isomer of cis-aconitic acid, are often used in Glycine max rotation systems. However, the effects of trans-Aconitic acid on Glycine max are unknown.
    METHODS AND RESULTS:
    We conducted a hydroponic experiment to evaluate the effects of 2.5–10 mM trans-Aconitic acid on Glycine max growth and photosynthesis. The results revealed that the enhanced H2O2 production in the roots increased the membrane permeability and reduced the water uptake. These effects culminated with a reduced stomatal conductance (gs), which seems to be the main cause for a decreased photosynthetic rate (A). Due to low gs, the limited CO2 assimilation may have overexcited the photosystems, as indicated by the high production of H2O2 in leaves. After 96 h of incubation, and due to H2O2-induced damage to photosystems, a probable non-stomatal limitation for photosynthesis contributed to reducing A. This is corroborated by the significant decrease in the quantum yield of electron flow through photosystem II in vivo (ΦPSII) and the chlorophyll content.
    CONCLUSIONS:
    Taken together, the damage to the root system and photosynthetic apparatus caused by trans-Aconitic acid significantly reduced the Glycine max plant growth.
    In vivo:
    Biomedicine & Pharmacotherapy, 2018, 99:87-95.
    Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis.[Reference: WebLink]
    trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. Esterification was explored as a strategy to increase lipophilicity and biopharmaceutical properties of TAA, a highly polar tricarboxylic acid. We herein report the synthesis of TAA esters via Fischer esterification with ethanol, n-butanol and n-octanol.
    METHODS AND RESULTS:
    The reaction kinetics was investigated to produce mono-, di- and tri- derivatives. Mono- and diesters of TAA were obtained as a mixture of positional isomers, whereas the triesters were recovered as pure compounds. The obtained esters were screened in a model of acute arthritis induced by the injection of LPS in the knee joint of Swiss mice. The diesters were the most active compounds, regardless of the alcohol employed in the reaction, whereas bioactivity of the derivatives improved by increasing the length of the aliphatic chain of the alcohol employed in esterification. In general, the esters showed higher potency than TAA. When administered orally to mice at doses of 0.017-172.3 μmol/Kg, the diethyl, di-n-butyl and di-n-octyl esters of TAA reduced the cellular infiltration into the knee joint, especially of neutrophils.
    CONCLUSIONS:
    The study identified diesters of TAA as potential useful derivatives for the management of rheumatoid arthritis and other inflammatory diseases.
    trans-Aconitic acid Description
    Source: The herbs of Asarum europaeum L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.7438 mL 28.7191 mL 57.4383 mL 114.8765 mL 143.5956 mL
    5 mM 1.1488 mL 5.7438 mL 11.4877 mL 22.9753 mL 28.7191 mL
    10 mM 0.5744 mL 2.8719 mL 5.7438 mL 11.4877 mL 14.3596 mL
    50 mM 0.1149 mL 0.5744 mL 1.1488 mL 2.2975 mL 2.8719 mL
    100 mM 0.0574 mL 0.2872 mL 0.5744 mL 1.1488 mL 1.436 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Biochemical medicine and metabolic biology, 1989, 42(3):171-178.
    Evaluation of antileishmanial activity of trans-aconitic acid.[Reference: WebLink]

    METHODS AND RESULTS:
    TAA(trans-Aconitic acid), an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote form in vitro was also inhibited by 2 mm TAA. TAA also reduced multiplication of the parasite in macrophage culture.
    CONCLUSIONS:
    In the hamster model of leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day.
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