Natural Products
| Catalog No. | Information |
| CFN96090 | 2',4',6'-Trihydroxyacetophenone 2',4',6'-Trihydroxyacetophenone has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity. |
| CFN96091 | Ethyl 2,4,6-trihydroxybenzoate Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. |
| CFN96092 | Harman Harman exhibits neuroactive activity in the human body. |
| CFN96093 | 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one has cytotoxic activities and tumour-selectivities, it also has hypoglycemic activity. |
| CFN96094 | Gamma-Methoxyisoeugenol Methyl Isoeugenol has antioxidant activity. |
| CFN96095 | 11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide 11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide is a natural product from Paeonia lactiflora. |
| CFN96096 | (16R)-E-Isositsirikine Reference standards. |
| CFN96097 | 10-Hydroxy-16-epiaffinine Standard reference |
| CFN96098 | Randaiol Randaiol is a natural product from Magnolia hypoleuca. |
| CFN96099 | erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol Reference standards. |
| CFN96100 | threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol Reference standards. |
| CFN96101 | Antirhine Standard reference |
| CFN96102 | Moracin O Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 uM. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. |
| CFN96103 | 3-Phenyl-1-(pyrrol-1-yl)propan-1-one Reference standards. |
| CFN96104 | 3-(4-Methoxyphenyl)-1-(pyrrol-1-yl)propan-1-one Reference standards. |
| CFN96105 | 1-Cinnamoylpyrrole Reference standards. |
| CFN90577 | Dehydrotrametenolic acid Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug; it can be a potential anticancer agent against H-ras transformed tumor. |
| CFN90578 | 3,6'-Disinapoyl sucrose 3,6'-Disinapoyl sucrose has neuroprotective effect and antidepressive activity in rats, at least in part, by increasing expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF). 3,6'-Disinapoyl sucrose protect neuron cells from glutamate-induced excitotoxicity include the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2. |
| CFN90290 | Oxysophoridine Oxysophoridine has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1.Oxysophoridine ameliorates cardiac damage in a rat model of AMI and that this cardioprotection may be linked with its anti-oxidative, anti-apoptotic and anti-inflammatory properties. |
| CFN90579 | Deacetylcinobufagin Deacetylcinobufagin shows the potent activities against human carcinoma cervicis (Hela) and malignant melanoma (A375) cells in vitro. |
| CFN90580 | 3,4-Dimethoxybenzyl Alcohol |
| CFN90581 | Columbamine Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. It shows strong acetylcholinesterase (AChE) inhibitory activity with IC50 48.1 μM. |
| CFN90582 | (-)-Isocorypalmine (-)-Isocorypalmine has significant antifungal activity. l-isocorypalmine acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction. |
| CFN90583 | Tetrahydrocurcumin Tetrahydrocurcumin can inhibit tumor angiogenesis, treat human breast cancer,and be a promising candidate for the prevention of CIPN by chemotherapeutic agents.Tetrahydrocurcumin exhibits protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation; it has a protective effect over arsenic induced toxicity in rat. |
| CFN90584 | Octahydrocurcumin Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-κB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity. |
| CFN90585 | Dihydrorotenone Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway. |
| CFN90586 | L-Quebrachitol L-Quebrachitol can as a sugar substitute for diabetics. Administration of sea buckthorn juice enriched in L-quebrachitol can increase fasting insulin level in plasma and show similar effects on random blood glucose level, glucose tolerance and the pancreatic tissue as observed for pure sea buckthorn juice. |
| CFN90587 | Abietic acid Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.Abietic acid acts as a PPARα/γ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-κB and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing. Abietic acid can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis. |
| CFN90588 | Primin Primin has antimycobacterial, and strong antineoplastic actions. Primin has potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and low cytotoxicity (IC50 15.4 microM) on mammalian cells; it could serve as a lead compound for the rational design of more potent and less toxic antiprotozoal agents. |
| CFN90589 | Myristicin Myristicin has anti-cholinergic, antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin may antagonize the anxiolytic effects of midazolam, increase anxiety, and affect motor movements. Myristicin can induce apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, caspase-3 activation, PARP-cleavage and DNA fragmentation. |
| CFN90590 | Cnidilin Cnidilin has high BBB permeability and has pharmacokinetic potentials for the treatment of central nervous system diseases. |
| CFN90591 | 8-Hydroxybergapten 8-Hydroxybergapten may have anti-wrinkle activity. |
| CFN90592 | Bergamotine Bergamotine can significantly reduce blood glucose and increase glucose tolerance and insulin sensitivity in KK-Aydiabetic mice. |
| CFN90593 | Daphnetin 7-methyl ether Daphnetin 7-methyl ether has anti-inflammatory activity. |
| CFN90594 | Daphnetin dimethyl ether Daphnetin dimethyl ether is a product from Wikstroemia indica (Linn.) C. A. Mey. |
| CFN90595 | Oxyimperatorin Oxyimperatorin is a natural product from Angelica dahurica. |
| CFN90596 | Taccalonolide A Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects. |
| CFN90602 | Taccalonolide B Taccalonolide B displays microtubule stabilizing activity.Several taccalonolides have in vitro antitrypanosomal activity against Trypanosoma brucei brucei and EC50 values for the isolated compounds were from 0.79 ug/mL. |
| CFN90603 | Sarcosine Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist, it preconditioning induces ischemic tolerance against global cerebral ischemia and this neuroprotective state is associated with changes in glycine transport and reduction of NR2B-containing NMDAR expression.Sarcosine modulates endothelial cell function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway. |
| CFN90604 | Dehydrocorydaline nitrate Dehydrocorydaline has anti-inflammatory activity, it has antinociceptive effects in mouse models of inflammatory pain, the effects involve the opioid receptor and inflammatory cytokines. Dehydrocorydaline can inhibit elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages.Dehydrocorydaline not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to dehydrocorydaline. |
| CFN90605 | Tetramethylcurcumin Tetramethylcurcumin is a natural product from Curcuma rcenyujin. |
| CFN90606 | Naringenin chalcone Naringenin chalcone has antiallergic, anti-inflammatory ,and anti-asthmatic properties, it inhibits the production of proinflammatory cytokines in the interaction between adipocytes and macrophages, and improves adipocyte metabolic functions and exerts insulin-sensitizing effects by activating an adiponectin-related pathway. |
| CFN90607 | Dimethylcurcumin Dimethylcurcumin is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion. |
| CFN90608 | Dihydrocholesterol Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Dihydrocholesterol is equally effective in reducing plasma cholesterol as β-sitosterol at a low dose, which is mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion. |
| CFN90609 | 27-Hydroxycholesterol 27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor, it may negatively modulate cognitive effects and cholesterol metabolism in the brain. 27-Hydroxycholesterol can enhance cell release of IL-8, IL-1β, and TNF-α and to upregulate matrix metalloproteinase-9 (MMP-9) via TLR4/NF-κB-dependent pathway; it also can reduce hepatic inflammation in hyperlipidemic mice. |
| CFN90610 | 7Beta-Hydroxycholesterol 7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells. |
| CFN90611 | 4-Beta-Hydroxycholesterol 4-Beta-hydroxycholesterol is a new endogenous CYP3A marker. 4-Beta-Hydroxycholesterol has exceptionally slow elimination and high plasma concentration properties, may it is a potential role of 4-Beta-Hydroxycholesterol as a ligand for the nuclear. |
| CFN90612 | Tokinolide B Tokinolide B may have sedative and spasmolytic properties. |
| CFN90613 | Precyasterone Reference standards. |
| CFN90614 | 17-Hydroxy sprengerinin C Reference standards. |
