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    Natural Products
    Auraptenol
    Information
    CAS No. 1221-43-8 Price $318 / 5
    Catalog No.CFN99340Purity>=98%
    Molecular Weight260.3 Type of CompoundCoumarins
    FormulaC15H16O4Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $324.1 / In-stock
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    Auraptenol

    Auraptenol
    Product Name Auraptenol
    CAS No.: 1221-43-8
    Catalog No.: CFN99340
    Molecular Formula: C15H16O4
    Molecular Weight: 260.3 g/mol
    Purity: >=98%
    Type of Compound: Coumarins
    Physical Desc.: Powder
    Targets: 5-HT Receptor
    Source: The fruits of Citrus aurantium
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 5
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  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
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  • Food Chem.2019, 279:80-87
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Molecules.2021, 26(13):4081.
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  • The Journal of Supercritical Fluids2021, 176:105305.
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  • J Mater Chem B.2019, 7(39):5896-5919
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Analgesia Compound Library
  • Antidepressant Compound Library
  • Coumarins Compound Library
  • 5-HT Receptor Inhibitor Library
  • Biological Activity
    Description: Auraptenol possesses robust antidepressant-like efficacy in mice. It has potential to be a novel analgesic for the management of neuropathic pain, it attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors. Auraptenol shows high inhibitory activities against larval settlement of Balanus albicostatus with EC50values of 3.38 ug m/L.
    Targets: 5-HT Receptor
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.
    [Coumarins from Leonurus japonicus and their anti-platelet aggregative activity].[Pubmed: 25850267]
    Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18.
    METHODS AND RESULTS:
    Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , Auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time.
    CONCLUSIONS:
    In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
    Int J Mol Sci. 2013 Jan 9;14(1):1197-206.
    Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae.[Pubmed: 23303279]

    METHODS AND RESULTS:
    In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and Auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2'-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) were synthesized from osthole. Compounds 1, 2, 4, 7 showed high inhibitory activities against larval settlement of Balanus albicostatus with EC(50) values of 4.64, 3.39, 3.38, 4.67 μg mL-1. Compound 8 could significantly inhibit larval settlement of Bugula neritina with an EC(50) value of 3.87 μg mL-1.
    CONCLUSIONS:
    The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5' and C-2'/C-3' of isoamylene chian could affect the AF activities.
    In vivo:
    Sci Rep. 2013 Nov 29;3:3377.
    Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors.[Pubmed: 24287473]
    Common chemotherapeutic agents such as vincristine often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is refractory to common analgesics and represents a challenging clinical issue. Angelicae dahuricae radix is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the active component(s) that attribute to the analgesic action have not been identified.
    METHODS AND RESULTS:
    This work described the anti-hyperalgesic effect of one coumarin component, Auraptenol, in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. We reported that Auraptenol dose-dependently reverted the mechanical hyperalgesia in mice within the dose range of 0.05-0.8 mg/kg. In addition, the anti-hyperalgesic effect of Auraptenol was significantly blocked by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). Within the dose range studied, Auraptenol did not significantly alter the general locomotor activity in mice.
    CONCLUSIONS:
    Taken together, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust analgesic efficacy in mice. These data support further studies to assess the potential of Auraptenol as a novel analgesic for the management of neuropathic pain.
    Auraptenol Description
    Source: The fruits of Citrus aurantium
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Sci Rep. 2014 Mar 24;4:4433.
    Antidepressant-like effects of auraptenol in mice.[Pubmed: 24658501]
    Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society. Current available antidepressants are not adequate to meet the clinical needs.
    METHODS AND RESULTS:
    Here we report that Auraptenol, an active component of the traditional Chinese medicine, angelicae dahuricae radix, had antidepressant-like effects in mice models of depression. In mouse forced swimming test and tail suspension test, two validated models of depression, Auraptenol dose-dependently decreased the immobility duration within the dose range of 0.05-0.4 mg/kg. In addition, the antidepressant-like effects of Auraptenol was significantly averted by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). These doses that affected the immobile response did not affect locomotor activity.
    METHODS AND RESULTS:
    In summary, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust antidepressant-like efficacy in mice. These data support further exploration for the possibility of developing Auraptenol as a novel antidepressant agent in the treatment of major depression disorders.
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