bis[6-(5,6-dihydrochelerythrinyl)]amine | CAS:165393-48-6

bis[6-(5,6-dihydrochelerythrinyl)]amine

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Description:

BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).

Targets:

Antifection

In vitro:

Planta Med. 2011 Sep;77(13):1542-4.

Chemical constituents, antimicrobial and antimalarial activities of Zanthoxylum monophyllum.[Pubmed: 21341176]

METHODS AND RESULTS:
From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3',4'-methylenedioxylignan-4,8,9,9'-tetraol (1), has been isolated along with 22 known compounds (2- 23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities.
CONCLUSIONS:
Alkaloids BIS-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 μM) while compound 5,8,4'-trihydroxy-3,7,3'-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.

bis[6-(5,6-dihydrochelerythrinyl)]amine Description

Source:	The herbs of Macleaya cordata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	bis[6-(5,6-dihydrochelerythrinyl)]amine
Price:
CAS No.:	165393-48-6
Catalog No.:	CFN91015
Molecular Formula:	C₄₂H₃₇N₃O₈
Molecular Weight:	711.76 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Macleaya cordata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.405 mL	7.0248 mL	14.0497 mL	28.0994 mL	35.1242 mL
5 mM	0.281 mL	1.405 mL	2.8099 mL	5.6199 mL	7.0248 mL
10 mM	0.1405 mL	0.7025 mL	1.405 mL	2.8099 mL	3.5124 mL
50 mM	0.0281 mL	0.1405 mL	0.281 mL	0.562 mL	0.7025 mL
100 mM	0.014 mL	0.0702 mL	0.1405 mL	0.281 mL	0.3512 mL

CFN99749	Acetylcorynoline	18797-80-3	409.43	C₂₃H₂₃NO₆
CFN90319	Chelidonine	476-32-4	353.37	C₂₀H₁₉NO₅
CFN90127	Dihydrochelerythrine	6880-91-7	349.38	C₂₁H₁₉NO₄
CFN92737	Norchelerythrine	6900-99-8	333.3	C₂₀H₁₅NO₄
CFN97999	Oxychelerythrine	28342-33-8	363.4	C₂₁H₁₇NO₅
CFN98909	Decarine	54354-62-0	319.3	C₁₉H₁₃NO₄
CFN98109	Nitidine chloride	13063-04-2	383.83	C₂₁H₁₈ClNO₄
CFN98259	Sanguinarine	2447-54-3	332.3	C₂₀H₁₄NO₄
CFN92810	Dihydrosanguinarine	3606-45-9	333.1	C₂₀H₁₅NO₄
CFN89299	6-Methoxydihydrosanguinarine	72401-54-8	363.36	C₂₁H₁₇NO₅