Natural Products
| Catalog No. | Information |
| CFN90990 | Tsugaric acid A Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage. |
| CFN93676 | Fuscaxanthone C Fuscaxanthone C is a natural product from Garcinia mangostana. |
| CFN92486 | Astringin Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production. Astringinin can significantly attenuate proinflammatory responses and hepatic injury after trauma-hemorrhage, the salutary effects of astringinin administration on attenuation of hepatic injury following trauma-hemorrhage are likely due to reduction of pro-inflammatory mediator levels. |
| CFN92490 | Cytidine Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.Cytidine deaminases APOBEC3G and APOBEC3F interact with human immunodeficiency virus type 1 integrase and inhibit proviral DNA formation. |
| CFN93252 | Androsin Androsin has antiasthmatic effects , it can prevent allergen- and platelet-activating factor (PAF)-induced bronchial obstruction (10 mg/kg orally; 0.5 mg inhalative). |
| CFN92467 | Angelic anhydride Reference standards. |
| CFN93216 | Kukoamine B Kukoamine B is a potent dual inhibitor for both Lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA), LPS and CpG DNA are important pathogenic molecules for the induction of sepsis,are drug targets for sepsis treatment, thus kukoamine B is worthy of further investigation as a potential candidate to treat sepsis. Kukoamine B may potentially serve as an agent for prevention of several human neurodegenerative and other disorders caused by oxidative stress, it has protective effects against hydrogen peroxide (H2O2) induced cell injury and potential mechanisms in SH-SY5Y cells. |
| CFN92489 | Tinnevellin glucoside Tinnevellin glucoside is a natural product from Cassia angustifolia. |
| CFN93653 | Brevifolincarboxylic acid Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony, it (IC50 = 18.0 uM) also shows good antioxidant activity. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent. |
| CFN90888 | Phloretic acid Phloretic acid may have antifungal activity. |
| CFN90889 | Sodium Dichloroacetate Sodium dichloroacetate is a drug with potential for treating patients with stroke and head injury. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3; it is cytoprotective to some colorectal cancer cells under hypoxic conditions. |
| CFN90931 | Quercetin Dihydrate Quercetin dihydrate loaded electrospun nanofibrous membrane show antimycotic effect on candida albicans. Clinoptilolite modified with quercetin dihydrate has shown better cytotoxicity compared with clinoptilolite modified with quercetin. The supplementation of quercetin dihydrate and gallate promotes an increase in fecal sterols, which in turn leads to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol. |
| CFN90930 | Tomatine Tomatine is a natural glycoalkaloid with anti-inflammatory, fungicidal, antimicrobial, and insecticidal properties. alpha-Tomatine activates phosphotyrosine kinase and monomeric G-protein signaling pathways leading to Ca(2+) elevation and ROS burst in F. oxysporum cells. |
| CFN93007 | Guggulsterone E&Z Guggulsterone E&Z is a natural product from Ailanthus grandis, it did not show antimicrobial activity. |
| CFN93253 | Ecliptasaponin A Ecliptasaponin A has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-mesenchymal transition. |
| CFN93096 | 2''-O-Beta-L-Galorientin Reference standards. |
| CFN93585 | Quercetin-3-gentiobioside Quercetin-3-gentiobioside may show significant inhibitor on AR and AGEs formation activities. |
| CFN90928 | Cyclopamine Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay, it can increase levels of p27, and decreases both expression of IGF-II and activation of Akt in PC-3 prostate cancer cells. Cyclopamine as a novel, potent inhibitor of human breast cancer proliferation and estrogen responsiveness that could potentially be developed into a promising therapeutic agent for the treatment of breast cancer. Cyclopamine also can suppress the growth of leukemia and lymphoma cells. |
| CFN93577 | Cratoxylone 1. Cratoxylone exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with the IC₅₀ value belows 3 uM. |
| CFN93288 | Kinsenoside Kinsenoside shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it could promote the glucose tolerance of acute glucose increase in both diabetic and normal healthy rats. Kinsenoside inhibits osteoclastogenesis from macrophages by attenuating RANKL-induced NF-κB and NFATc1 activities, which in turn, prevents bone loss from OVX mice. |
| CFN93260 | Platycodin D2 Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalacin D2 has anti-cancer activity, it exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines. |
| CFN93051 | Kushenol F Kushenol F is a tyrosinase inhibitor, it shows significant inhibitory effects on monoamine oxidase ( in a dose-dependent manner with IC50 values of 69.9 microM). Kushenol F preferentially inhibits the MAO-B activity than MAO-A activity with the IC50 values of 63.1 and 103.7 microM, respectively. |
| CFN90922 | Ingenol-3,4:5,20-diacetonide Reference standards. |
| CFN90923 | Ingenol-5,20-acetonide Reference standards. |
| CFN90924 | Ingenol 3-Angelate Ingenol-3-angelate shows anticancer activity, and P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of ingenol-3-angelate in vivo; it activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCdelta. Ingenol-3-angelate suppresses HIV infection of primary CD4+ T cells through down-modulation of cell surface expression of HIV co-receptors. Ingenol-3-angelate emerges as a unique local chemotherapeutic immunostimulatory debulking agent that could be used in conjunction with immunotherapies to promote regression of metastases. |
| CFN93281 | Germacrene D The sesquiterpene germacrene D (GD) activates a major type of olfactory receptor neuron on the antennae of the heliothine moths, it can increase attraction and oviposition by the tobacco budworm moth Heliothis virescens. |
| CFN90991 | Beta-Elemonic acid Beta-Elemonic acid exhibits anti-inflammatory, and anti-cancer effects, it inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities. |
| CFN90929 | Veratramine Veratramine exhibits cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Veratramine shows hypotensive effect, the effect is directly positively correlated with the dosage. |
| CFN93151 | Glucoraphanin Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, it has antioxidant activity, it induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. Glucoraphanin can ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Glucoraphanin and Glucoerucin effectively act as antagonists for the aryl hydrocarbon receptor, and this may contribute to their established chemoprevention potency. |
| CFN93199 | Methylnissolin-3-O-glucoside (6aR,11aR)-9,10-Dimethoxypterocarpan 3-O-β-D-glucoside(Methylnissolin-3-O- glucoside) has antioxidant activity. |
| CFN93187 | Luteolin-3-O-beta-D-glucuronide Luteolin 3'-O-beta-D-glucuronide is active in the inhibition of nitrite production in macrophages. |
| CFN90925 | Guanosine Guanosine and GMP show anticonvulsant properties, which may be related with antagonism of glutamate receptors; they also prevent seizures induced by quinolinic acid in mice.Guanosine protects against renal ischemic injury by replenishing GTP stores and preventing tubular apoptosis. |
| CFN93115 | Parishin E Parishin E is a natural product from Gastrodia elata. |
| CFN93372 | Gypenoside XLVI Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml. |
| CFN93368 | Escin IA Escin IA is a prodrug and its structure can be converted to desacylescin I by human intestinal bacteria and Lactobacillus brevis., desacylescin I as a biotransformation product shows potentially inhibitory effects on mouse tumor, and a potential candidate for anti tumor agents. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of EMT process by down-regulating LOXL2 expression. |
| CFN90927 | Hydroxytyrosol acetate Hydroxytyrosol acetate has antibacterial, neuroprotective , antioxidant and anti-inflammatory effects, it can enhance the fluorescent intensity of DNA binding molecules and mediated supercoiled DNA relaxation. Hydroxytyrosol acetate can improve the oxidative events and return pro-inflammatory proteins expression to basal levels probably through JAK/STAT, MAPKs and NF-κB pathways. Hydroxytyrosol acetate and polyphenols hydroxytyrosol administered orally can inhibit platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contributed to this effect. |
| CFN90921 | 5-O-Demethylnobiletin 5-O-Demethylnobiletin has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. |
| CFN90944 | Dehydroevodiamine Dehydroevodiamine has anticholinesterase activity and an anti-amnesic effect, it also may be a novel and effective ligand for improvement of beta-amyloid type amnesia. Dehydroevodiamine has antiarrhythmic, and anti-inflammatory properties, the effect of dehydroevodiamine-mediated inhibition of the expression LPS-induced iNOS and COX-2 genes is due to under the suppression of NF-kappaB activation in the transcriptional level. |
| CFN90911 | Desoxyrhaponticin Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. Desoxyrhaponticin could be considered as a promising fatty acid synthase(FAS) inhibitor, it could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. |
| CFN93555 | Ranaconitine Ranaconitine has cardiotoxicity. |
| CFN90919 | Cephalotaxine Cephalotaxine is an antiviral as well as antitumor agent. It is useless for the treatment of infection by flaviviruses, but potentially useful in combined therapy against hepatitis B. |
| CFN93284 | Notoginsenoside Fa Notoginsenosides Fa and R4 show significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells. |
| CFN90955 | Jervine Jervine exhibits cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249, it induces COX-2 overexpression in human erythroleukemia cells. Jervine exhibits potent toxic effects against Colorado potato beetle. |
| CFN90969 | Tiglic acid Tiglic acid shows antiviral activity toward herpes simplex virus type 1. |
| CFN90916 | Tubeimoside III Tubeimoside III has anti-inflammatory, anti-tumor, and anti-tumorigenic activities, stronger than those of tubeimoside II. It has acute toxicity, stronger than that of tubeimoside II. |
| CFN90915 | Tubeimoside II Tubeimoside I, tubeimoside II, and tubeimoside III show anti-inflammatory, antitumor, and antitumor-promo ting effects. |
| CFN90802 | Acetovanillone Acetovanillone is the NADPH oxidase inhibitor, induces oxidative stress. |
| CFN90852 | Fucoxanthin Fucoxanthin shows anti-obesity, antioxidant, anti-inflammatory, chemopreventive and/or chemotherapeutic effects. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. Fucoxanthin suppresses the inflammation of endotoxin-induced uveitis by blocking the iNOS and COX-2 protein expression and its anti-inflammatory effect on eye is comparable with the effect of predinisolone used in similar doses. |
| CFN90886 | Irinotecan hydrochloride Irinotecan hydrochloride is a water soluble topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer. |
| CFN90977 | Isoastragaloside I Isoastragaloside I may be promising in modulating CCl4-induced lethality and most of its toxic effects. Astragaloside II and Isoastragaloside I are sufficient to ameliorate insulin resistance, they may provide the lead as a novel class of therapeutics for obesity-related diseases. |
