Licoisoflavanone | CAS:66067-26-3 | Manufacturer ChemFaces

Licoisoflavanone

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Description:

Licoisoflavanone is a natural product from Licorice.

In vivo:

J Pharm Biomed Anal. 2015 Nov 10;115:515-22.

Metabolites identification of bioactive licorice compounds in rats.[Pubmed: 26311472 ]

Licorice (Glycyrrhiza uralensis Fisch.) is one of the most popular herbal medicines worldwide. This study aims to identify the metabolites of seven representative bioactive licorice compounds in rats.
METHODS AND RESULTS:
These compounds include 22β-acetoxyl glycyrrhizin (1), licoflavonol (2), licoricidin (3), Licoisoflavanone (4), isoglycycoumarin (5), semilicoisoflavone B (6), and 3-methoxy-9-hydroxy-pterocarpan (7). After oral administration of 250mg/kg of 1 or 40mg/kg of 2-7 to rats, a total of 16, 43 and 31 metabolites were detected in the plasma, urine and fecal samples, respectively. The metabolites were characterized by HPLC/DAD/ESI-MS(n) and LC/IT-TOF-MS analyses. Particularly, two metabolites of 1 were unambiguously identified by comparing with reference standards, and 22β-acetoxyl glycyrrhizin-6″-methyl ester (1-M2) is a new compound. Compound 1 could be readily hydrolyzed to eliminate the glucuronic acid residue.
CONCLUSIONS:
The phenolic compounds (4-7) mainly undertook phase II metabolism (glucuronidation or sulfation). Most phenolic compounds with an isoprenyl group (chain or cyclized, 2-5) could also undertake hydroxylation reaction. This is the first study on in vivo metabolism of these licorice compounds.

Licoisoflavanone Description

Source:	The roots of Licorice.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Molecules. 2009 Oct 9;14(10):3942-51.

Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'.[Pubmed: 19924040 ]

San-ao decoction (SAD), comprising Herba Ephedrae, Radix et Rhizoma Glycyrrhizae and Seneb Armeniacae Amarum, is one of the most popular traditional Chinese medicine (TCM) formulae for asthma. Peroxisome proliferator-activated receptors (PPARs) areey regulators of lipid and glucose metabolism and have become important therapeutic targets for various deseases, PPARgamma activation might exhibit anti-inflammatory properties in different chronic inflammatory processes.
METHODS AND RESULTS:
The EtOAc fraction of SAD showed a significant effect on PPARgamma activation. A simple and rapid method has been established for separation and characterization of the main compounds in the PPARgamma-activating fraction of SAD by ultra-fast HPLC coupled with quadropole time-of-flight mass pectrometry (UPLC-Q-TOF/MS). A total of 10 compounds were identified in the activating fraction of SAD, including amygdalin (1), liquiritin (2), 6'-acetyliquiritin (3), liquiritigenin (4), isoliquiritigenin (5), formononetin (6), Licoisoflavanone (7), glycycoumarin (8), glycyrol (9) and uercetin (10). The results also characterized formononetin as a predominant component in this fraction.
CONCLUSIONS:
The dose-effect relationship comparison study of formononetin and the EtOAc fraction of SAD by adding formononetin was performed, the results suggested that formononetin was the major component of the EtOAc fraction of SAD responsible for activating PPARgamma, and the method will possibly be applied to study the complex biological active constituents of other TCMs.

Product Name	Licoisoflavanone
Price:	$338 / 5mg
CAS No.:	66067-26-3
Catalog No.:	CFN96544
Molecular Formula:	C₂₀H₁₈O₆
Molecular Weight:	354.36 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Licorice.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.822 mL	14.1099 mL	28.2199 mL	56.4398 mL	70.5497 mL
5 mM	0.5644 mL	2.822 mL	5.644 mL	11.288 mL	14.1099 mL
10 mM	0.2822 mL	1.411 mL	2.822 mL	5.644 mL	7.055 mL
50 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.1288 mL	1.411 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.5644 mL	0.7055 mL

CFN96544	Licoisoflavanone	66067-26-3	354.36	C₂₀H₁₈O₆
CFN94013	Glyasperin F	145382-61-2	354.35	C₂₀H₁₈O₆
CFN95073	Dihydrolicoisoflavone	164163-92-2	356.4	C₂₀H₂₀O₆
CFN95084	5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone	141846-47-1	424.5	C₂₅H₂₈O₆
CFN97240	5-Deoxycajanin	7622-53-9	284.3	C₁₆H₁₂O₅
CFN97931	Dalbergioidin	30368-42-4	288.3	C₁₅H₁₂O₆
CFN99257	2'-Hydroxygenistein	1156-78-1	286.2	C₁₅H₁₀O₆
CFN80045	Lupinalbin A	98094-87-2	284.03	C₁₅H₈O₆
CFN97861	Barpisoflavone A	101691-27-4	300.27	C₁₆H₁₂O₆
CFN98419	Cajanin	32884-36-9	300.3	C₁₆H₁₂O₆